• Introduction
• API Development and Manufacture
  • Medicinal Chemistry Support
  • First in Man (Rapidd™)
  • Intermediate and API Supplies
  • Supporting Capabilities
• Solid State Services
  • Polymorph Screening Service
  • Crystal Engineering
  • Crystal Form Selection
  • Characterisation
  • Pharma Expert Witness
• Analytical
  • Method Development and Validation
  • Physical and Chemical Characterisation
  • Product Testing
  • Stability Testing
  • Facilities and Instrumentation
• Peptides and Proteins
  • GMP Peptide API
  • Custom Peptides
  • Immunograde Peptides
  • Chemokines
  • Site Specific PEGylation
    • Ligation Technology
    • Application to PEGylation
  • Facilities and Equipment
  • Quote
• Isotope Chemistry
  • Chemistry
  • Analysis
  • cGMP
  • Labels
• Biocatalysis
  • Biocatalysis Services
  • Biocatalysis Expertise
  • Enzyme Kits
  • Process Development
  • Chiral Building Blocks
  • Enzyme Screening
  • Fermentation & Molecular Biology
  • Purification
  • Enzyme Kit Quotation Request

Intermediate & API Supplies

From raw material sourcing to distributed drug product we provide a total supply chain for your drug.

We are committed to providing our customers with manufacturing solutions embedding fit-for-purpose technology that works today.

Our focus is to deliver Quality, On Time, In Full - QUOTIF.

We manufacture: small molecules; peptides; oligonucleotides; proteins; and peptide-cytotoxic conjugates from gramme to tonne scale. Our experienced process development chemists rigorously develop and challenge the processes, determining process controls, identifying impurities, ensuring their control and determining their purge and fate characteristics. The development cycle is completed with process validation in preparation for final regulatory approval of the process.

Facilities

We have a range of facilities delivering grammes to multi tonne scale intermediates and API for clinical and commercial requirements. These include:

• Kilo labs for rapid delivery of First In Human supplies
• Contained facilities for the manufacture of potent and cytotoxic compounds
• Class 10,000 facilities for the manufacture and purification of peptides
• Chromatographic equipment for rapid purification
• Micronisation equipment
  

We have extended our manufacturing capability by developing relationships with selected manufacturing companies across the globe enabling delivery of a total supply chain solution for our customers regardless of the phase of clinical development.

Micronisation
As part of our suite of services linking API manufacture to formulation and drug product manufacture we micronise from gramme to tonne scale. The microniser is located within containment facilities providing containment to 1 microgramme/m3.
A wide range of particle distributions can be achieved including provision of material suitable for use in inhalers.

The full range of particle sizing services is provided through:
• Particle size determination
- dry powder
- wet dispersion
• Hot stage microscopy with photography
• DSC
• XRPD

In combination with our extensive capabilities in solid state services, we design the particle that you want for the product that you want.

Analytical
All of our manufacturing activities are underpinned by our powerful analytical capabilities: analytical method development and validation; impurity identification; stability studies; Click for more.