• Introduction
• API Development and Manufacture
  • Medicinal Chemistry Support
  • First in Man (Rapidd™)
  • Intermediate and API Supplies
  • Supporting Capabilities
• Solid State Services
  • Polymorph Screening Service
  • Crystal Engineering
  • Crystal Form Selection
  • Characterisation
  • Pharma Expert Witness
• Analytical
  • Method Development and Validation
  • Physical and Chemical Characterisation
  • Product Testing
  • Stability Testing
  • Facilities and Instrumentation
• Peptides and Proteins
  • GMP Peptide API
  • Custom Peptides
  • Immunograde Peptides
  • Chemokines
  • Site Specific PEGylation
    • Ligation Technology
    • Application to PEGylation
  • Facilities and Equipment
  • Quote
• Isotope Chemistry
  • Chemistry
  • Analysis
  • cGMP
  • Labels
• Biocatalysis
  • Biocatalysis Services
  • Biocatalysis Expertise
  • Enzyme Kits
  • Process Development
  • Chiral Building Blocks
  • Enzyme Screening
  • Fermentation & Molecular Biology
  • Purification
  • Enzyme Kit Quotation Request

Polymorph Screening Service

Given that about 80% of pharmaceuticals exhibit polymorphism, choosing an appropriate form demands a thorough and systematic approach to screening and characterisation.  Pharmaceutical forms can range from pure crystalline or non-crystalline (amorphous) compounds to multi-component systems, including salts, solvates, hydrates, and cocrystals.

A combination of screening techniques is the most effective route towards new forms!

Almac screens are designed to match compound characteristics with client requirements:

• Structure / property analysis
• Mini screens to exhaustive screening, discovering and characterising as many forms as possible

Enabled by:

• Diverse crystallisation techniques: cooling; evaporation; anti-solvent addition; seeding
• Solid state manipulation: grinding; micronisation; melting and sublimation.